Targetable Metabolic Vulnerability in Diffuse Large B-Cell Lymphoma
نویسندگان
چکیده
منابع مشابه
Targetable Metabolic Vulnerability in Diffuse Large B-Cell Lymphoma
Targeting metabolic alterations has become a promising therapeutic Of note, altering lipid metabolism, KDACI subsequently modulates strategy in treating hematological malignancies nowadays. Recurrent mutations of metabolic enzyme isocitrate dehydrogenase (IDH) are identified in acute myeloid leukemia and proven critically involved in leukemogenesis. AG-211, a small-molecular inhibitor of mutant...
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The enzyme serine hydroxymethyltransferse (SHMT) converts serine into glycine and a tetrahydrofolate-bound one-carbon unit. Folate one-carbon units support purine and thymidine synthesis, and thus cell growth. Mammals have both cytosolic SHMT1 and mitochondrial SHMT2, with the mitochondrial isozyme strongly up-regulated in cancer. Here we show genetically that dual SHMT1/2 knockout blocks HCT-1...
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ژورنال
عنوان ژورنال: EBioMedicine
سال: 2018
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2018.01.036